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Benzonatate
Tessalon (benzonatate) is a small molecule pharmaceutical. Benzonatate was first approved as Tessalon on 1982-01-01. It is used to treat cough and hiccup in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Tessalon (generic drugs available since 1993-01-29)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Benzonatate
Tradename
Company
Number
Date
Products
TESSALONMylanN-011210 RX1982-01-01
1 products, RLD
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
benzonatateANDA2023-06-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
coughHP_0012735D003371R05
hiccup—D006606R06.6
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R05: Cough and cold preparations
— R05D: Cough suppressants, excl. combinations with expectorants
— R05DB: Other cough suppressants in atc
— R05DB01: Benzonatate
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBENZONATATE
INNbenzonatate
Description
Benzonatate is the ester obtained by formal condensation of 4-butylaminobenzoic acid with nonaethylene glycol monomethyl ether. Structurally related to procaine and benzocaine, it has an anaesthetic effect on the stretch sensors in the lungs, and is used as a non-narcotic cough suppressant. It has a role as an antitussive and an anaesthetic. It is a benzoate ester, a substituted aniline and a secondary amino compound. It is functionally related to a 4-(butylamino)benzoic acid and a nonaethylene glycol monomethyl ether.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCNc1ccc(C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)cc1
Identifiers
PDB—
CAS-ID104-31-4
RxCUI18993
ChEMBL IDCHEMBL1374379
ChEBI ID3032
PubChem CID7699
DrugBankDB00868
UNII ID5P4DHS6ENR (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 213 documents
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Safety
Black-box Warning
Black-box warning for: Benzonatate
Adverse Events
Top Adverse Reactions
0 adverse events reported
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