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Atracurium
Tracrium (atracurium) is a small molecule pharmaceutical. Atracurium was first approved as Tracrium preservative free on 1983-11-23. It is known to target neuronal acetylcholine receptor subunit alpha-4, neuronal acetylcholine receptor subunit alpha-7, acetylcholine receptor subunit alpha, and neuronal acetylcholine receptor subunit alpha-3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atracurium besylate
Tradename
Company
Number
Date
Products
TRACRIUMHospiraN-018831 DISCN1985-06-20
1 products, RLD
TRACRIUM PRESERVATIVE FREEHospiraN-018831 DISCN1983-11-23
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
atracurium besylateANDA2022-11-01
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
M03: Muscle relaxants
M03A: Muscle relaxants, peripherally acting agents
M03AC: Other quaternary ammonium compounds in atc, muscle relaxants, peripherally acting
M03AC04: Atracurium
HCPCS
No data
Clinical
Clinical Trials
177 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Attention deficit disorder with hyperactivityD001289EFO_0003888F9021427421397
SchizophreniaD012559EFO_0000692F20131217
Parkinson diseaseD010300EFO_0002508G2011215
Substance-related disordersD019966EFO_0003890F132215
Marijuana abuseD002189EFO_0007191F12314
Orthostatic hypotensionD007024I95.11113
DyslexiaD004410EFO_0005424F81.033
Autistic disorderD001321EFO_0003758F84.0123
Attention deficit and disruptive behavior disordersD019958HP_0010865F91.3213
DepressionD003863F33.9112
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fetal alcohol spectrum disordersD063647Q86.0112
NeoplasmsD009369C8011
Alzheimer diseaseD000544EFO_0000249F03111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Obstructive sleep apneaD020181EFO_0003918G47.3351010
Cocaine-related disordersD019970F142114
Opioid-related disordersD009293EFO_0005611F11112
Orthostatic intoleranceD054971212
Memory disordersD00856922
Cognitive dysfunctionD060825G31.8422
TachycardiaD013610HP_0001649R00.0111
Down syndromeD004314EFO_0001064Q9011
Sleep apnea syndromesD012891EFO_0003877G47.311
Physiological stressD013312111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pure autonomic failureD054970112
Healthy volunteers/patients11
Alcohol-induced disordersD02075111
Type 1 diabetes mellitusD003922EFO_0001359E1011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Anorexia nervosaD000856EFO_0004215F50.011
Multiple system atrophyD01957811
Parkinsonian disordersD020734HP_000130011
StrokeD020521EFO_0000712I63.911
Transient ischemic attackD002546EFO_0003764G45.911
MenopauseD008593EFO_0003922N9511
Whiplash injuriesD01491111
NeurofeedbackD05876511
Morbid obesityD009767EFO_000107411
Traumatic brain injuriesD000070642S0611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameATRACURIUM
INNatracurium besilate
Description
Atracurium besylate is the bisbenzenesulfonate salt of atracurium. It has a role as a nicotinic antagonist and a muscle relaxant. It is a quaternary ammonium salt and an organosulfonate salt. It contains an atracurium.
Classification
Small molecule
Drug classquaternary ammonium derivatives: neuromuscular blocking agents
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC
Identifiers
PDB
CAS-ID64228-79-1
RxCUI1219
ChEMBL IDCHEMBL1360
ChEBI ID2914
PubChem CID47320
DrugBankDB00732
UNII ID40AX66P76P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRNA4
CHRNA4
CHRNA7
CHRNA7
CHRNA1
CHRNA1
CHRNA3
CHRNA3
Organism
Homo sapiens
Gene name
CHRNA4
Gene synonyms
NACRA4
NCBI Gene ID
Protein name
neuronal acetylcholine receptor subunit alpha-4
Protein synonyms
cholinergic receptor, nicotinic alpha 4, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 4, neuronal nicotinic acetylcholine receptor alpha-4 subunit
Uniprot ID
Mouse ortholog
Chrna4 (11438)
neuronal acetylcholine receptor subunit alpha-4 (Q9ET51)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20,078 adverse events reported
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