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Amoxapine
Asendin (amoxapine) is a small molecule pharmaceutical. Amoxapine was first approved as Asendin on 1982-01-01. It is used to treat depressive disorder, psychophysiologic disorders, and psychotic affective disorders in the USA. The pharmaceutical is active against sodium-dependent noradrenaline transporter and sodium-dependent serotonin transporter. In addition, it is known to target 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 2A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amoxapine
Tradename
Company
Number
Date
Products
ASENDINLederle LaboratoriesN-018021 DISCN1982-01-01
4 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
amoxapineANDA2015-02-28
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
depressive disorderEFO_1002014D003866F32.A
psychophysiologic disordersD011602F45.9
psychotic affective disordersD000341F39
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N06: Psychoanaleptics
N06A: Antidepressants
N06AA: Non-selective monoamine reuptake inhibitors
N06AA17: Amoxapine
HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute kidney injuryD058186HP_0001919N1711114
AnesthesiaD000758123
Post-dural puncture headacheD051299112
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.911
Chronic renal insufficiencyD051436N1811
Heart blockD006327I45.8911
Inferior wall myocardial infarctionD056989EFO_100098311
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AsthmaD001249EFO_0000270J45123
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart arrestD006323EFO_0009492I4611
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Altitude sicknessD000532EFO_1000782T70.2922
Pulmonary hypertensionD006976EFO_0001361I27.2011
Premature obstetric laborD007752O6011
Urinary bladder neoplasmsD001749C6711
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R5211
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMOXAPINE
INNamoxapine
Description
Amoxapine is a dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position. It has a role as an antidepressant, an adrenergic uptake inhibitor, a dopaminergic antagonist, a serotonin uptake inhibitor and a geroprotector.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2
Identifiers
PDB
CAS-ID14028-44-5
RxCUI722
ChEMBL IDCHEMBL1113
ChEBI ID2675
PubChem CID2170
DrugBankDB00543
UNII IDR63VQ857OT (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A2
SLC6A2
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A2
Gene synonyms
NAT1, NET1, SLC6A5
NCBI Gene ID
Protein name
sodium-dependent noradrenaline transporter
Protein synonyms
NET, neurotransmitter transporter, Norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, solute carrier family 6 member 5
Uniprot ID
Mouse ortholog
Slc6a2 (20538)
sodium-dependent noradrenaline transporter (Q6QU62)
Alternate
HTR6
HTR6
HTR2C
HTR2C
HTR7
HTR7
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 951 documents
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Safety
Black-box Warning
Black-box warning for: Amoxapine
Adverse Events
Top Adverse Reactions
Mock data
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690 adverse events reported
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