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Norvasc, Copalia(amlodipine)
Amturnide, Amvaz, Azor, Caduet, Consensi, Copalia, Dafiro, Exforge, Katerzia, Lotrel, Norliqva, Norvasc, Prestalia, Rasilamlo, Rasitrio, Tekamlo, Tribenzor, Twynsta (amlodipine) is a small molecule pharmaceutical. Amlodipine was first approved as Norvasc on 1992-07-31. It is used to treat coronary artery disease, hypertension, and variant angina pectoris in the USA. It has been approved in Europe to treat hypertension. It is known to target voltage-dependent L-type calcium channel subunit alpha-1D and voltage-dependent L-type calcium channel subunit alpha-1C.
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Top Prescription Drugs
Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Katerzia, Norliqva, Norvasc (generic drugs available since 2007-05-23, discontinued: Amvaz)
Combinations
Azor, Caduet, Exforge, Lotrel, Prestalia, Tribenzor (generic drugs available since 2007-05-23, discontinued: Amturnide, Consensi, Tekamlo, Twynsta)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aliskiren hemifumarate
+
Amlodipine besylate
Tradename
Company
Number
Date
Products
TEKAMLONovartisN-022545 DISCN2010-08-26
4 products
Hide discontinued
Aliskiren hemifumarate
+
Amlodipine besylate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
AMTURNIDENovartisN-200045 DISCN2010-12-21
5 products
Hide discontinued
Amlodipine benzoate
Tradename
Company
Number
Date
Products
KATERZIAAzurityN-211340 RX2019-07-08
1 products, RLD, RS
Amlodipine besylate
Tradename
Company
Number
Date
Products
NORLIQVACMP PharmaN-214439 RX2022-02-24
1 products, RLD, RS
NORVASCViatrisN-019787 RX1992-07-31
3 products, RLD, RS
Show 1 discontinued
Amlodipine besylate
+
Atorvastatin calcium
Tradename
Company
Number
Date
Products
CADUETPharmacia & UpjohnN-021540 RX2004-01-30
11 products, RLD, RS
Amlodipine besylate
+
Benazepril hydrochloride
Tradename
Company
Number
Date
Products
LOTRELNovartisN-020364 RX1995-03-03
6 products, RLD
Amlodipine besylate
+
Celecoxib
Tradename
Company
Number
Date
Products
CONSENSIPurple BiotechN-210045 DISCN2018-05-31
3 products, RLD
Hide discontinued
Amlodipine besylate
+
Hydrochlorothiazide
+
Olmesartan medoxomil
Tradename
Company
Number
Date
Products
TRIBENZORCosette Pharmaceuticals N-200175 RX2010-07-23
5 products, RLD, RS
Amlodipine besylate
+
Hydrochlorothiazide
+
Valsartan
Tradename
Company
Number
Date
Products
EXFORGE HCTNovartisN-022314 RX2009-04-30
5 products, RLD, RS
Amlodipine besylate
+
Olmesartan medoxomil
Tradename
Company
Number
Date
Products
AZORCosette Pharmaceuticals N-022100 RX2007-09-26
4 products, RLD, RS
Amlodipine besylate
+
Perindopril arginine
Tradename
Company
Number
Date
Products
PRESTALIAAdhera TherapeuticsN-205003 RX2015-01-21
3 products, RLD, RS
Amlodipine besylate
+
Telmisartan
Tradename
Company
Number
Date
Products
TWYNSTABoehringer IngelheimN-022401 DISCN2009-10-16
4 products, RLD
Hide discontinued
Amlodipine besylate
+
Valsartan
Tradename
Company
Number
Date
Products
EXFORGENovartisN-021990 RX2007-06-20
4 products, RLD, RS
Amlodipine maleate
Tradename
Company
Number
Date
Products
AMVAZDr Reddys LaboratoriesN-021435 DISCN2003-10-31
3 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amlodipine and benazepril hydrochlorideANDA2023-06-20
amlodipine and valsartanANDA2023-05-20
azorNew Drug Application2022-06-17
caduetNew Drug Application2021-03-25
exforge hctNew Drug Application2022-03-09
katerziaNew Drug Application2020-10-28
lotrelNew Drug Application2022-03-09
norliqvaNew Drug Application2022-02-28
norvascNew Drug Application2022-04-04
prestaliaNew Drug Application2019-10-25
Show 1 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
coronary artery diseaseD003324I25.1
hypertensionEFO_0000537D006973I10
variant angina pectorisD000788I20.1
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Amlodipine Besylate, Norliqva, Cmp Dev Llc
112534742041-02-24DPU-3309, U-3310, U-3311
114580952041-02-24DPU-3309, U-3310, U-3311
Amlodipine Benzoate, Katerzia, Azurity
107994532039-04-11DP
106953292037-10-16DP
108940392037-10-06U-3, U-185
109529982037-10-06DP
109599912037-10-06U-39, U-158
113642302037-10-06DP
114714092037-10-06U-3447, U-3448
114844982037-10-06DP
Amlodipine Besylate / Celecoxib, Consensi, Purple Biotech
103501712038-06-14DP
109258352038-06-14U-2410
109459602038-06-14DP
94088372030-02-28U-2410
96623152029-05-22DPU-2410
Aliskiren Hemifumarate / Amlodipine Besylate, Tekamlo, Novartis
86139492029-12-21DP
Amlodipine Besylate / Perindopril Arginine, Prestalia, Adhera
78469612029-10-05DS, DPU-3
66964812023-04-15DS, DPU-3
Amlodipine Besylate / Hydrochlorothiazide / Valsartan, Exforge Hct, Novartis
81015992023-05-16DP
84758392023-05-16DP
Aliskiren Hemifumarate / Amlodipine Besylate / Hydrochlorothiazide, Amturnide, Novartis
81832952023-05-16DP
ATC Codes
C: Cardiovascular system drugs
C07: Beta-adrenergic blocking agents
C07F: Beta blocking agents, other combinations
C07FB: Beta blocking agents and calcium channel blockers
C07FB07: Bisoprolol and amlodipine
C07FB12: Nebivolol and amlodipine
C07FB13: Metoprolol and amlodipine
C08: Calcium channel blockers
C08C: Selective calcium channel blockers with mainly vascular effects
C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
C08CA01: Amlodipine
C08CA51: Amlodipine and celecoxib
C08G: Calcium channel blockers and diuretics
C08GA: Calcium channel blockers and diuretics
C08GA02: Amlodipine and diuretics
C09: Agents acting on the renin-angiotensin system
C09B: Ace inhibitors, combinations
C09BB: Ace inhibitors and calcium channel blockers
C09BB03: Lisinopril and amlodipine
C09BB04: Perindopril and amlodipine
C09BB07: Ramipril and amlodipine
C09BX: Ace inhibitors, other combinations in atc
C09BX01: Perindopril, amlodipine and indapamide
C09BX03: Ramipril, amlodipine and hydrochlorothiazide
C09BX04: Perindopril, bisoprolol and amlodipine
C09D: Angiotensin ii receptor blockers (arbs), combinations
C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
C09DB01: Valsartan and amlodipine
C09DB02: Olmesartan medoxomil and amlodipine
C09DB04: Telmisartan and amlodipine
C09DB05: Irbesartan and amlodipine
C09DB06: Losartan and amlodipine
C09DB07: Candesartan and amlodipine
C09DB09: Fimasartan and amlodipine
C09DX: Angiotensin ii receptor blockers (arbs), other combinations
C09DX01: Valsartan, amlodipine and hydrochlorothiazide
C09DX03: Olmesartan medoxomil, amlodipine and hydrochlorothiazide
C09DX06: Candesartan, amlodipine and hydrochlorothiazide
C09DX07: Irbesartan, amlodipine and hydrochlorothiazide
C09X: Other agents acting on the renin-angiotensin system in atc
C09XA: Renin-inhibitors
C09XA53: Aliskiren and amlodipine
C09XA54: Aliskiren, amlodipine and hydrochlorothiazide
C10: Lipid modifying agents
C10B: Lipid modifying agents, combinations
C10BX: Lipid modifying agents in combination with other drugs
C10BX03: Atorvastatin and amlodipine
C10BX07: Rosuvastatin, amlodipine and lisinopril
C10BX09: Rosuvastatin and amlodipine
C10BX11: Atorvastatin, amlodipine and perindopril
C10BX14: Rosuvastatin, amlodipine and perindopril
C10BX18: Atorvastatin, amlodipine and ramipril
HCPCS
No data
Clinical
Clinical Trials
544 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10432210111928308
Essential hypertensionD000075222I104102412552
HyperlipidemiasD006949EFO_0003774E78.51317324
DyslipidemiasD050171HP_0003119367117
HypercholesterolemiaD006937HP_00031243519
Type 2 diabetes mellitusD003924EFO_0001360E11189
Diabetes mellitusD003920EFO_0000400E08-E132428
Blood pressureD001794EFO_000432577
ObesityD009765EFO_0001073E66.912417
Metabolic syndromeD024821EFO_0000195E88.8111417
Show 33 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cognitive dysfunctionD060825G31.84234
Cerebral hemorrhageD002543213
Beta-thalassemiaD017086Orphanet_848D56.11123
Heart diseasesD006331EFO_0003777I51.91113
Vascular dementiaD015140F01112
Iron overloadD019190112
ThalassemiaD013789EFO_1001996D56122
Erectile dysfunctionD007172EFO_0004234F52.21112
Myocardial infarctionD009203EFO_0000612I21112
Coronary diseaseD003327112
Show 8 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Insulin resistanceD007333EFO_0002614112
Abdominal aortic aneurysmD017544EFO_0004214112
NeoplasmsD009369C8011
Abdominal obesityD056128HP_000195611
Triple negative breast neoplasmsD064726111
Iga vasculitisD011695EFO_1000965D69.0111
HyperaldosteronismD006929HP_0011736E2611
PancreatitisD010195EFO_0000278K85111
Dystonic disordersD020821G2411
Vascular diseasesD014652EFO_0004264I7711
Show 2 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients69473
Therapeutic equivalencyD01381022
Hiv infectionsD015658EFO_0000764B2011
FastingD005215EFO_000275611
HivD006678O98.711
Drug interactionsD00434711
Hepatitis cD006526B19.211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Stable anginaD060050I20.822
Orthostatic hypotensionD007024I95.111
Renal dialysisD006435EFO_0010690Z99.211
PharmacokineticsD01059911
Morbid obesityD009767EFO_000107411
InfertilityD007246EFO_000054511
Lung diseasesD008171EFO_0003818J98.411
Hyperlipoproteinemia type iiD006938EFO_0004911E78.0011
Lower urinary tract symptomsD059411EFO_000800811
Diabetes complicationsD04890911
Show 4 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMLODIPINE
INNamlodipine
Description
Amlodipine is a fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina. It has a role as an antihypertensive agent, a calcium channel blocker and a vasodilator agent. It is a dihydropyridine, a member of monochlorobenzenes, an ethyl ester, a methyl ester and a primary amino compound.
Classification
Small molecule
Drug classphenylpyridine vasodilators; tricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
Identifiers
PDB
CAS-ID88150-42-9
RxCUI
ChEMBL IDCHEMBL1491
ChEBI ID2668
PubChem CID2162
DrugBankDB00381
UNII ID1J444QC288 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CACNA1D
CACNA1D
CACNA1C
CACNA1C
Organism
Homo sapiens
Gene name
CACNA1D
Gene synonyms
CACH3, CACN4, CACNL1A2, CCHL1A2
NCBI Gene ID
Protein name
voltage-dependent L-type calcium channel subunit alpha-1D
Protein synonyms
calcium channel, L type, alpha-1 polypeptide, Calcium channel, L type, alpha-1 polypeptide, isoform 2, calcium channel, neuroendocrine/brain-type, alpha 1 subunit, calcium channel, voltage-dependent, L type, alpha 1D subunit, voltage-gated calcium channel alpha 1 subunit, voltage-gated calcium channel alpha subunit Cav1.3, Voltage-gated calcium channel subunit alpha Cav1.3
Uniprot ID
Mouse ortholog
Cacna1d (12289)
voltage-dependent L-type calcium channel subunit alpha-1D (Q99246)
Variants
Clinical Variant
No data
Financial
Exforge - Novartis
$
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Caduet - Pfizer
$
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Norvasc - Viatris
$
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Norvasc - Pfizer
$
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Prestalia - Adhera Therapeutics
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19,166 documents
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Safety
Black-box Warning
Black-box warning for: Amlodipine and benazepril hydrochloride, Amlodipine and valsartan, Azor, Exforge hct, Lotrel, Prestalia, Tribenzor
Adverse Events
Top Adverse Reactions
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1,025 adverse events reported
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