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Alosetron
Lotronex (alosetron) is a small molecule pharmaceutical. Alosetron was first approved as Lotronex on 2000-02-09. It is used to treat abdominal pain, diarrhea, and irritable bowel syndrome in the USA. It is known to target 5-hydroxytryptamine receptor 3A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Lotronex (generic drugs available since 2015-05-04)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alosetron hydrochloride
Tradename
Company
Number
Date
Products
LOTRONEXSebela PharmaceuticalsN-021107 RX2000-02-09
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
alosetron hydrochlorideANDA2022-05-25
lotronexNew Drug Application2019-05-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
abdominal painHP_0002027D015746R10.9
diarrheaHP_0002014D003967R19.7
irritable bowel syndromeEFO_0000555D043183K58
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A03: Drugs for functional gastrointestinal disorders
A03A: Drugs for functional gastrointestinal disorders
A03AE: Serotonin receptor antagonists for functional gastrointestinal disorders
A03AE01: Alosetron
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic hyperplasiaD011470EFO_0000284N40167216
Prostatic diseasesD011469N42.9112
Lower urinary tract symptomsD059411EFO_0008008112
Choroid diseasesD015862HP_0000610H31.911
Renal colicD056844EFO_1001412N2311
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Kidney calculiD007669EFO_0004253N20.0213
Neurogenic urinary bladderD001750HP_0000011N3133
Urinary retentionD016055HP_0000016R33213
Erectile dysfunctionD007172EFO_0004234F52.21112
Multiple sclerosisD009103EFO_0003885G35111
HydronephrosisD006869EFO_0005562N13.3011
Urinary calculiD014545N20.911
Prostatic neoplasmsD011471C6111
Ureteral calculiD01451411
ColicD003085HP_0011848R10.8311
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ConstipationD003248HP_0002019K59.011
NephrolithiasisD053040N20.011
UrolithiasisD052878N20-N2311
UreterolithiasisD053039EFO_1001228N20.111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute diseaseD00020811
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALOSETRON
INNalosetron
Description
Alosetron is a pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position. It has a role as a serotonergic antagonist, an antiemetic and a gastrointestinal drug. It is a pyridoindole and a member of imidazoles.
Classification
Small molecule
Drug classserotonin 5-HT3 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O
Identifiers
PDB
CAS-ID122852-42-0
RxCUI85248
ChEMBL IDCHEMBL1110
ChEBI ID253342
PubChem CID2099
DrugBankDB00969
UNII ID13Z9HTH115 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR3A
HTR3A
Organism
Homo sapiens
Gene name
HTR3A
Gene synonyms
5HT3R, HTR3
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 3A
Protein synonyms
5-HT-3, 5-HT3R, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic, 5-hydroxytryptamine receptor 3, 5HT3 serotonin receptor, Serotonin receptor 3A, Serotonin-gated ion channel receptor
Uniprot ID
Mouse ortholog
Htr3a (15561)
5-hydroxytryptamine receptor 3A (Q61226)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 967 documents
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Safety
Black-box Warning
Black-box warning for: Alosetron hydrochloride, Lotronex
Adverse Events
Top Adverse Reactions
Mock data
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3,125 adverse events reported
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