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Campath , Mabcampath(alemtuzumab)
Campath, Lemtrada (alemtuzumab) is an antibody pharmaceutical. Alemtuzumab was first approved as Campath on 2001-05-07. It is used to treat b-cell chronic lymphocytic leukemia in the USA. It has been approved in Europe to treat b-cell chronic lymphocytic leukemia and multiple sclerosis. The pharmaceutical is active against CAMPATH-1 antigen.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
nervous system diseasesD009422
hemic and lymphatic diseasesD006425
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Campath, Lemtrada
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Alemtuzumab
Tradename
Proper name
Company
Number
Date
Products
LemtradaalemtuzumabGenzyme CorporationN-103948 RX2014-11-14
1 products
Campath alemtuzumabGenzyme CorporationN-103948 RX2004-10-12
1 products
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
campathBiologic Licensing Application2020-10-29
lemtradaBiologic Licensing Application2021-03-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
b-cell chronic lymphocytic leukemiaD015451C91.1
Agency Specific
FDA
EMA
Expiration
Code
alemtuzumab, Campath , Genzyme Corporation
2108-05-07Orphan excl.
alemtuzumab, Lemtrada, Genzyme Corporation
2108-05-07Orphan excl.
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L04: Immunosuppressants
L04A: Immunosuppressants
L04AA: Selective immunosuppressants
L04AA34: Alemtuzumab
HCPCS
Code
Description
J0202
Injection, alemtuzumab, 1 mg
Clinical
Clinical Trials
304 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G353232817
Kidney transplantationD0160303625316
Relapsing-remitting multiple sclerosisD020529EFO_00039292439
Kidney diseasesD007674EFO_0003086N082314
Renal insufficiencyD051437HP_0000083N192224
Chronic kidney failureD007676EFO_0003884N18.61213
Graft rejectionD0060841113
VasculitisD014657EFO_0006803M31112
Chronic inflammatory demyelinating polyradiculoneuropathyD020277EFO_1000868G61.8111
Granulomatosis with polyangiitisD014890EFO_0005297M31.311
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C9510382344
B-cell chronic lymphocytic leukemiaD015451C91.17282538
Sickle cell anemiaD000755EFO_0000697D5711202126
Myelodysplastic syndromesD009190D46620222
Aplastic anemiaD000741HP_0001915D61.92101213
Myeloid leukemia acuteD015470C92.03719
T-cell lymphoma peripheralD016411C84.92719
ThalassemiaD013789EFO_1001996D566117
Extranodal nk-t-cell lymphomaD054391C86.0314
Diamond-blackfan anemiaD029503D61.011313
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.9924230
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0614116
Non-hodgkin lymphomaD008228C85.989215
Hodgkin diseaseD006689C81311112
Graft vs host diseaseD006086D89.8137110
Myeloproliferative disordersD009196D47.13619
Multiple myelomaD009101C90.0499
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340388
Lymphoproliferative disordersD008232Orphanet_2442D47.92718
Hematologic neoplasmsD0193374517
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD00854511
Germ cell and embryonal neoplasmsD00937311
Gastrointestinal stromal tumorsD046152EFO_0000505C49.A11
Rhabdoid tumorD01833511
Ewing sarcomaD012512EFO_000017311
RhabdomyosarcomaD01220811
Large cell carcinomaD01828711
Wilms tumorD00939611
Neuroepithelial neoplasmsD01830211
Rheumatoid arthritisD001172EFO_0000685M06.911
Show 5 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lysosomal storage diseasesD01646411
Hematopoietic stem cell transplantationD01838011
Hemoglobin sc diseaseD006450EFO_1001797D57.211
Kidney neoplasmsD007680EFO_0003865C6411
B-cell lymphomaD01639311
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALEMTUZUMAB
INNalemtuzumab
Description
Immunoglobulin G 1 (human-rat monodonal CAMPATH-1H 71-chain anti-human antigen CD52), disulfide with human-rat monoclonal CAMPATH-1H light chain, dimer
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)ALEMTUZUMAB
Structure (InChI/SMILES or Protein Sequence)
>1CE1:H|PROTEIN (CAMPATH-1H:HEAVY CHAIN) QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQ FSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE >1CE1:L|PROTEIN (CAMPATH-1H:LIGHT CHAIN) DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQP EDIATYYCLQHISRPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
Identifiers
PDB1BEY, 1BFO, 1CE1, 6OBD
CAS-ID216503-57-0
RxCUI117055
ChEMBL IDCHEMBL1201587
ChEBI ID
PubChem CID
DrugBankDB00087
UNII ID3A189DH42V (ChemIDplus, GSRS)
Target
Agency Approved
CD52
CD52
Organism
Homo sapiens
Gene name
CD52
Gene synonyms
CDW52, HE5
NCBI Gene ID
Protein name
CAMPATH-1 antigen
Protein synonyms
Cambridge pathology 1 antigen, CD52, CD52 antigen (CAMPATH-1 antigen), CDw52, CDW52 antigen (CAMPATH-1 antigen), Epididymal secretory protein E5, epididymis secretory sperm binding protein Li 171mP, He5, HEL-S-171mP, Human epididymis-specific protein 5
Uniprot ID
Mouse ortholog
Cd52 (23833)
CAMPATH-1 antigen (Q64389)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 11,703 documents
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Safety
Black-box Warning
Black-box warning for: Campath, Lemtrada
Adverse Events
Top Adverse Reactions
Mock data
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3,660 adverse events reported
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