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Adapalene
Differin, Epiduo (adapalene) is a small molecule pharmaceutical. Adapalene was first approved as Differin on 1996-05-31. It is used to treat acne vulgaris in the USA. The pharmaceutical is active against retinoic acid receptor gamma and retinoic acid receptor beta. In addition, it is known to target retinoic acid receptor alpha.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Differin (generic drugs available since 2010-06-02)
Combinations
Epiduo (generic drugs available since 2010-06-02)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Adapalene
Tradename
Company
Number
Date
Products
DIFFERINGaldermaN-020380 OTC2016-07-08
1 products, RLD, RS
DIFFERINGaldermaN-020748 RX2000-05-26
1 products, RLD, RS
DIFFERINGaldermaN-021753 RX2007-06-19
1 products, RLD, RS
DIFFERINGaldermaN-022502 RX2010-03-17
1 products, RLD, RS
Show 1 discontinued
Adapalene
+
Benzoyl peroxide
Tradename
Company
Number
Date
Products
EPIDUO FORTEGaldermaN-207917 RX2015-07-15
1 products, RLD, RS
EPIDUOGaldermaN-022320 RX2008-12-08
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
adapalene gel usp, 0.3% ANDA2023-05-06
differin daily deep cleanser with bpo OTC monograph final2023-05-18
epiduo forteNew Drug Application2021-08-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Adapalene, Differin, Galderma Labs Lp
79984672028-05-31DPU-1078
84355022026-09-15DPU-1078
87093922026-09-15DPU-1078
75793772025-02-23U-818
77371812024-08-29DP
78340602023-03-12U-1078
78385582023-03-12DP
78680442023-03-12U-1078
87038202023-03-12U-1078
Adapalene / Benzoyl Peroxide, Epiduo, Galderma Labs Lp
80716442027-07-18DPU-1078
80805372027-07-18U-1078
81293622027-07-18U-1078
84455432027-07-12U-1078
78201862025-11-23DP
79642022024-09-01DPU-1078
Adapalene / Benzoyl Peroxide, Epiduo Forte, Galderma Labs
87291272023-03-12U-1078
93811792023-03-12U-1078
93871872023-03-12U-1078
ATC Codes
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AD: Retinoids for topical use in acne
— D10AD03: Adapalene
— D10AD53: Adapalene, combinations
HCPCS
No data
Clinical
Clinical Trials
31 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PsoriasisD011565EFO_0000676L40—3113522
ExanthemaD005076R21———1—1
Squamous cell neoplasmsD018307———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B201—1——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD008545—1———1
Alzheimer diseaseD000544EFO_0000249F03—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249————11
Liver diseasesD008107EFO_0001421K70-K77————11
HyperlipidemiasD006949EFO_0003774E78.5————11
DepressionD003863F33.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameADAPALENE
INNadapalene
Description
Adapalene is a naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether. It has a role as a dermatologic drug, a non-steroidal anti-inflammatory drug and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a monocarboxylic acid, a member of adamantanes and a naphthoic acid. It is functionally related to a CD437.
Classification
Small molecule
Drug classRetinoids
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2
Identifiers
PDB—
CAS-ID106685-40-9
RxCUI60223
ChEMBL IDCHEMBL1265
ChEBI ID31174
PubChem CID60164
DrugBankDB00210
UNII ID1L4806J2QF (ChemIDplus, GSRS)
Target
Agency Approved
RARG
RARG
RARB
RARB
Organism
Homo sapiens
Gene name
RARG
Gene synonyms
NR1B3
NCBI Gene ID
5916
Protein name
retinoic acid receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group B member 3, RAR-gamma
Uniprot ID
Q9UJ38
Mouse ortholog
Rarg (19411)
retinoic acid receptor gamma (P18911)
Alternate
RARA
RARA
Organism
Homo sapiens
Gene name
RARA
Gene synonyms
NR1B1
NCBI Gene ID
5914
Protein name
retinoic acid receptor alpha
Protein synonyms
Nuclear receptor subfamily 1 group B member 1, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form, PML-DDX5-RARA fusion, PML-DDX5-RARA fusion protein, RAR-alpha, retinoic acid receptor, alpha polypeptide
Uniprot ID
Q9NQS0
Mouse ortholog
Rara (19401)
retinoic acid receptor alpha (P11416)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,293 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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3,002 adverse events reported
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