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Acyclovir
Sitavig, Xerese, Zovirax (acyclovir) is a small molecule pharmaceutical. Acyclovir was first approved as Zovirax on 1982-03-29. It is used to treat aids-related opportunistic infections, chickenpox, epstein-barr virus infections, herpes genitalis, and herpes labialis amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
stomatognathic diseasesD009057
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Sitavig, Zovirax (generic drugs available since 1997-04-22, discontinued: Avaclyr, Zovirax)
Combinations
Xerese
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acyclovir
Tradename
Company
Number
Date
Products
ZOVIRAXBausch Health CompaniesN-018604 RX1982-03-29
1 products, RLD, RS
ZOVIRAXBausch Health CompaniesN-021478 RX2002-12-30
1 products, RLD
SITAVIGNovanN-203791 RX2013-04-12
1 products, RLD, RS
Show 4 discontinued
Acyclovir
+
Hydrocortisone
Tradename
Company
Number
Date
Products
XERESEBausch Health CompaniesN-022436 RX2009-07-31
1 products, RLD, RS
Acyclovir sodium
Tradename
Company
Number
Date
Products
ZOVIRAXGSKN-018603 DISCN1982-10-22
3 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
acyclovirANDA2023-06-20
sitavigNew Drug Application2020-06-11
xereseNew Drug Application2020-08-03
zoviraxNew Drug Application2021-02-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
aids-related opportunistic infectionsD017088
chickenpoxEFO_0007204D002644B01
epstein-barr virus infectionsEFO_0000769D020031
herpes genitalisEFO_0007282D006558A60
herpes labialisEFO_1001347D006560B00.1
herpes simplexD006561B00
herpes simplex encephalitisD020803B00.4
herpes zosterEFO_0006510D006562B02
herpes zoster ophthalmicusEFO_0007403D006563B02.3
Agency Specific
FDA
EMA
Expiration
Code
ACYCLOVIR, AVACLYR, FERA PHARMS LLC
2026-03-29ODE-235
Patent Expiration
Patent
Expires
Flag
FDA Information
Acyclovir, Sitavig, Epi Hlth
85924342030-06-16DPU-1460
87478962027-06-03DPU-1460
87911272027-03-23DPU-1460
ATC Codes
D: Dermatologicals
D06: Antibiotics and chemotherapeutics for dermatological use
D06B: Chemotherapeutics for topical use
D06BB: Antivirals, topical
D06BB03: Aciclovir
D06BB53: Aciclovir, combinations
J: Antiinfectives for systemic use
J05: Antivirals for systemic use
J05A: Direct acting antivirals
J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
J05AB01: Aciclovir
S: Sensory organ drugs
S01: Ophthalmologicals
S01A: Antiinfective ophthalmologics
S01AD: Antivirals, ophthalmologic
S01AD03: Aciclovir
HCPCS
Code
Description
J0133
Injection, acyclovir, 5 mg
Clinical
Clinical Trials
112 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2026731329
Herpes simplexD006561B0014101417
Herpes labialisD006560EFO_1001347B00.1147113
Herpes genitalisD006558EFO_0007282A60235212
Herpetic keratitisD016849EFO_0007308213
Healthy volunteers/patients112
Herpes zosterD006562EFO_0006510B02112
Relapsing-remitting multiple sclerosisD020529EFO_000392911
Viral pneumoniaD011024EFO_0007541J12.911
Papillomavirus infectionsD03036111
Show 2 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G35314
UlcerD014456MPATH_5792113
InfectionsD007239EFO_0000544112
ChickenpoxD002644EFO_0007204B01112
Respiratory tract infectionsD012141J06.911
Covid-19D000086382U07.111
Meniere diseaseD008575EFO_0006862H81.0111
Bone marrow transplantationD01602611
CytomegalovirusD00358711
CoinfectionD060085111
Show 4 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD00228911
Large b-cell lymphoma diffuseD016403C83.3111
Castration-resistant prostatic neoplasmsD06412911
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0111
Biphenotypic leukemia acuteD015456C95.0111
Philadelphia chromosomeD010677111
Kidney diseasesD007674EFO_0003086N08111
Kidney transplantationD016030111
Critical illnessD01663811
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neonatal sepsisD000071074HP_004018711
SimplexvirusD01813911
HemorrhoidsD006484EFO_0009552K6411
ObesityD009765EFO_0001073E66.911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lymphatic diseasesD008206HP_010076333
Aseptic meningitisD008582EFO_1000823G03.011
Cerebral hemorrhageD00254311
Subarachnoid hemorrhageD013345EFO_0000713I6011
Drug monitoringD01690311
Facial paralysisD005158G51.011
Molluscum contagiosumD008976EFO_0007375B08.111
UveitisD014605EFO_1001231H20.911
Acute kidney injuryD058186HP_0001919N1711
Repeat cesarean sectionD01760411
Show 6 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameACYCLOVIR
INNaciclovir
Description
Acyclovir is an oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. It has a role as an antiviral drug and an antimetabolite. It is an oxopurine and a member of 2-aminopurines. It is functionally related to a guanine.
Classification
Small molecule
Drug classantivirals: antivirals (acyclovir type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1nc2c(ncn2COCCO)c(=O)[nH]1
Identifiers
PDB
CAS-ID59277-89-3
RxCUI281
ChEMBL IDCHEMBL184
ChEBI ID2453
PubChem CID135398513
DrugBankDB00787
UNII IDX4HES1O11F (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 24,076 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,080 adverse events reported
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